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If you can't start an optimization you might have missed to set up all options. Please take care of messages in the infocenter at the very bottom of the Graphics Window!
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For an overview of the Warning & Error codes have a look here.
Warning & Error codes are displayed in the Studies tab by double clicking on the Meshless Generative Design Status
Furthermore, you can find warning and error messages during the optimization in the log-file log files in the result tab.Differentiated log files are saved in the project folder in your workspace (in the folder the optimization was started in). Further information here.
Possible mistakes for a non-running optimization:
No design space is selected - one object has to be selected
MSC Apex Generative Design 2019 works best with the binary stl file format. It can process the ASCII stl file format but there can be problems. Please try converting your stl file in a binary stl file and try again.
An stl file is missing in the project folderlog_error.log & log_warning.log). The log files are available as soon as a warning or error occurs during the optimisation.