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In one optimisation several Events (load cases) can be considered. Each Event is calculated by itself and the stresses / Failure Criteria of all Events are enveloped and the highest value for each area is considered. For information regarding the Event Specific Safety Factor have a look here.
The Stress / Failure Criterion calculation is from an FE point of view an estimation. That’s why we recommend a FE-Reanalysis using Apex Structures/Nastran to verify the results regarding all boundary conditions. For the reanalysis the Nominal-Geometry should be chosen which will be used after manufacturing and post manufacturing processes. The Reanalysis can also take dynamic loading & other boundary conditions into consideration that are not considered in the design process.
For further information regarding the stresses and Failure Criteria in the Post Processing, have a look here.