With the Loads & Boundary Condition Tools all Boundary Conditions can be created which are required for the optimisation. It can be chosen between Displacement Constraints and Structural Loads (directly or remotely applied).
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Pressure loads can be applied only on surfaces. It doesn’t matter if the surface is plane or not. The Pressure magnitude is the only value which is required. The chosen surface will automatically become a Nondesign space. If a pressure load is applied on a surface, no other Boundary Conditions can be applied on the same or any overlapping surfaces.